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Melatonin shows potential to slow tumor growth in certain breast cancers Date: January 28, 2014 Source: Henry Ford Health System Summary: An early stage study shows melatonin -- a hormone that regulates the body's sleep and awake cycles -- may have the potential to help slow the growth of certain breast cancer tumors, according to researchers.
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Strauss said. We have conventional treatments that are proven to be safe and effective and people are making individual decisions to neglect those therapies at some point.
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At night or in the dark, the pineal gland releases melatonin to regulate the sleep cycle.
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Altering the amount of one hormone in the body often alters the body's own production of other hormones.
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In their conclusion, the authors cautioned that chronic exposure to natural or artificial light and simultaneous intake of melatonin may potentially contribute to a significant loss of photoreceptor cells in the aging retina.
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Melatonin also alleviates some side effects of antipsychotics, such as weight gain and increased blood pressure.
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Reasonable increases in the dose of most opioids in response to poorly controlled pain do not tend to lead to an increased risk of adverse effects if a patient is tolerating the drug.
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In the study, the subjects, who did not know which treatment they were receiving, took melatonin an hour before bedtime for a period of weeks, then were switched to a dummy pill, or vice versa.
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There was a lack of good evidence, but guidance was offered nevertheless. Would we have been better off without any advice from the AAP.
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People who have a history of depression, in particular, should discuss the use of melatonin with their doctors before taking it.
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The pairing of a lack of melatonin secretion and synthesis with weight gain suggests that melatonin may either be anti-obesogenic (reducing fat gain) or may induce fat loss.
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Melatonin has been proposed as therapy of sleep disturbances including insomnia and jet lag, but it has not been approved for this indication in the United States.
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In those species there are indications that melatonin stimulates the release of gonadotropin-inhibitory hormone, in turn leading to the suppression of (hormones that act on the ovaries or testes), which may explain the disruptive effects on reproduction.
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Melatonin is produced by the pineal gland at night to regulate our circadian rhythm (sometimes called the sleep wake cycle).
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